| 1315-1317 | A series of hard winters, floods and famine strikes across northern Europe |
| 1323-1328 | Widespread peasant revolts in Flanders |
| 1333 | Harvest failure and famine in Catalonia |
| 1347 | Black Death arrives in Sicily |
| 1348-1349 | Black Death all across Europe |
| 1350-1351 | Black Death abates on the Continent but spreads to Scandinavia and Russia |
| 1358 | The Jacquerie in France |
| 1361 | Plague, sometimes called the Children's Plague |
| 1362 | Plague in England and the Netherlands |
| 1363 | Plague in the Netherlands |
| 1364 | Plague in the Netherlands |
| 1368 | Plague in England and the Netherlands |
| 1369 | Plague in England and the Netherlands |
| 1371 | Plague in Italy and the Netherlands |
| 1372 | Plague in Italy and the Netherlands |
| 1373 | Plague in Italy |
| 1374 | Plague in Italy |
| 1373 | Plague in England |
| 1378 | Ciompi Revolt in Florence |
| 1379 | Revolt in Ghent |
| 1381 | Peasants' Rebellion in England |
| 1382 | Plague in Italy and the Netherlands |
| The Harelle in Rouen (urban rebellion) | |
| The maillotins revolt in Paris | |
| 1383 | Plague in Italy and the Netherlands |
| 1384 | Plague in Italy and the Netherlands |
| 1390 | Plague in England |
| 1391 | Plague in England |
| 1400 | Plague in Italy, England and the Netherlands |
| 1401 | Plague in the Netherlands |
| 1405 | Plague in England |
| 1406 | Plague in England |
| 1409 | Plague in the Netherlands |
| 1410 | Plague in Gascony |
| 1411 | Plague in England and Gascony |
| 1412 | Plague in England |
| 1414 | Plague in England and Gascony |
| 1420 | Plague in the Netherlands |
| 1421 | Plague in the Netherlands |
| 1422 | Plague in Italy |
| 1423 | Plague in Italy and England |
| 1424 | Plague in Italy |
| 1425 | Plague in Italy |
| 1427 | Plague in Germany |
| 1428 | Plague in England |
| 1429 | Plague in England |
| 1433 | Plague in England |
| 1434 | Plague in England |
| 1435 | Plague in England |
| 1436 | Plague in Italy. Earthquake in Naples kills 30,000. |
| 1437 | Plague in Italy |
| 1438 | Plague in Italy, England and the Netherlands |
| 1439 | Plague in Italy, England and the Netherlands |
| 1447 | Plague in Italy |
| 1448 | Plague in Italy |
| 1449 | Plague in Italy |
| 1450 | Plague in Italy and the Netherlands |
| 1451 | Plague in Italy and the Netherlands |
| 1452 | Plague in the Netherlands |
| 1453 | Plague in the Netherlands |
| 1454 | Plague in the Netherlands |
| 1455 | Plague in the Netherlands |
| 1456 | Plague in the Netherlands |
| 1457 | Plague in the Netherlands |
| 1458 | Plague in the Netherlands |
| 1459 | Plague in the Netherlands |
| 1463 | Plague in England |
| 1464 | Plague in England |
| 1465 | Plague in England |
| 1466 | Plague in France and the Netherlands |
| 1467 | Plague in England and the Netherlands |
| 1468 | Plague in the Netherlands |
| 1469 | Plague in the Netherlands |
| 1470 | Plague in the Netherlands |
| 1471 | Plague in England and the Netherlands |
| 1472 | Plague in the Netherlands |
| 1477 | Plague in Naples |
| 1478 | Plague in Naples |
| 1479 | Plague in England and Italy |
| 1480 | Plague in England |
| 1481 | Plague in the Netherlands |
| 1482 | Plague in the Netherlands |
| 1485 | Plague in Naples |
| 1486 | Plague in Naples |
| 1487 | Plague in Naples and the Netherlands |
| 1488 | Plague in the Netherlands |
| 1489 | Plague in England and the Netherlands |
| 1490 | Plague in England and the Netherlands |
| 1492 | Plague in England and the Netherlands |
| 1493 | Plague in England, Naples, and the Netherlands |
| 1494 | Plague in England and the Netherlands |