The Jorcyk Laboratory of Inflammatory Cytokines in Tumor Invasion and Metastasis
Our laboratory’s research interests are in the area of inflammatory cytokines and their role in tumor invasion and metastasis. For approximately 20 years, we have focused on studying how the interleukin-6 (IL-6)-family member oncostatin M (OSM) contributes to breast carcinoma progression. Our lab has conducted some of the field’s first research on OSM and cancer metastasis, particularly to bone and lung. We have been the first to demonstrate that OSM promotes increased numbers of circulating tumor cells (CTCs) in mouse models of human breast cancer. Now we are addressing both how OSM interacts with IL-6 and promotes extracellular matrix remodeling in breast cancer metastasis. In addition, we have developed numerous cell lines and mouse tumor models of breast carcinoma.