From Misfolds to Fluorescence: Enhancing RNA Sensors for Biotechnological Breakthroughs
RNA, known for its complex 3D structure, serves as the basis for artificially developed sensors that emit fluorescence upon activation. My research delves into the challenges of misfolding in RNA sensors, particularly during self-assembly. By integrating principles from nucleic acid circuits and natural RNA switch design, the study aims to mitigate misfolding issues, ultimately enhancing the sensitivity and versatility of these sensors. The improved RNA sensors have implications for biotechnology and medicine, offering a promising avenue for cost- effective and rapid diagnostics.