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Limited Submission Notice: National Science Foundation, Regional Innovation Engines


National Science Foundation (NSF)


The NSF Regional Innovation Engines (NSF Engines) program supports the development of sustainable, inclusive, and geographically diverse regional innovation ecosystems that advance key technologies and address pressing regional, national, societal and/or geostrategic challenges. Unlike traditional NSF funding models, the NSF Engines program aims to catalyze and deepen the interactions among regional stakeholders with the explicit goal of catalyzing the establishment of a sustainable and inclusive ecosystem. Intentions of the program are to drive economic growth, create and retain quality jobs, expand equitable pathways into careers, and strengthen national competitiveness and security. The mission of an NSF Engine must be clearly rooted in regional interests and reflect the aspiration that a regional innovation ecosystem can help build strong communities where all residents can thrive.

For more information, view the full NSF Engines (NSF 24-565) solicitation.


$15 million for the first 2 years, not to exceed $160 million over a period of 10 years.

Limited Submission Requirements and Timeline:

This opportunity requires a Letter of Intent to be submitted to NSF, followed by a Preliminary Proposal, and if invited by NSF, the submission of a Full Proposal. One (1) Letter of Intent, Preliminary Proposal and Full Proposal per lead institution is allowed. The Principal Investigator (PI) must be a senior member of the submitting organization’s leadership and will also serve as the full-time CEO for the NSF Engine.

Only one (1) Letter of Intent approved by the Division of Research and Economic Development may be submitted to this program.

For such approval, Principal Investigators must first submit a Notice of Interest to by 4 pm on May 10, 2024. For the Notice of Intent, provide a brief description of the proposed Engine and its region of service.

**If necessary, a further white paper round may be required**

Key Submission Dates:

  • May 10, 2024 by 4 pm – Notice of Interest due to
  • May 17, 2024 – Anticipated date applicant will be notified of approval to advance toward Letter of Intent Submission
  • June 13, 2024 – Letter of Intent Materials due to OSP
  • June 18, 2024 – Letter of Intent due to NSF
  • July 29, 2024 – Preliminary Proposal Materials due to OSP
  • August 5, 2024 – Preliminary Proposal due to NSF
  • Mid-October – Full Proposal invitation date from NSF
  • February 4, 2025 – All final proposal documents due to OSP
  • February 11, 2025 – Full proposal due to NSF

Important Note on Sponsor Requirements:

  • An individual may serve as PI or co-PI on no more than one proposal submitted in response to this solicitation.

NOTE: Please send all inquiries and submissions for Limited Submission opportunities to